ARTÍCULOS ORIGINALES
Particulate bone matrix usage for alveolar
bone conservation. a histomorphometric study.
Sebastián Fontana1, Luis Plavnik1-2,
Miguel Filippetti3, Alicia Inés Malberti1
Revista Facultad de Ciencias Medicas 2013; 70(3):115-122
1 - Chair of Histology,
Dentistry Faculty, National University of Córdoba,
Argentina.
2 - Science and Technology Area, CREO Foundation, Córdoba,
Argentina.
3 - Human Tissue Processing Plant, UNC-Biotecnia, National
University of Córdoba, Argentina.
Correspondence:
Dra Alicia Malberti
Cátedra de Histología, Departamento de Biología Oral,
Facultad de Odontología.
Universidad Nacional de Córdoba (UNC). Haya de la Torre s/n,
Ciudad Universitaria CP: 5000. Córdoba, Argentina. e-mail:
inesmalberti@gmail.com
This project was funded by a
subsidy from the Secretariat of Science and Technology at
Córdoba National University (SeCyT, UNC. Res 162/12).
Abstract
Different filling materials have been used in an attempt to
repair bone loss situations.
Objective: The present study aimed to examine the effect of
a bone matrix in post-extraction remodelling of the alveolar
bone, and to perform a histomorphometric analysis of the
residual alveolar ridges in Wistar rats.
Material and Methods: Both rat first lower molars were
extracted and the right alveoli were filled with particles
of a bone matrix with mineral components (MO-UNC)
(experimental group, EG). The left alveoli were used as a
control group (CG). The animals were sacrificed at 0 hrs,
15, 30 and 60 days after extraction, and the samples were
processed. Histological sections were made at the level of
the mesial alveolus of the first lower molar. Repair of the
alveoli was histologically evaluated and a histomorphometric
study of total alveolar volume (TAV), height of the buccal
plate (Bh), height of the lingual plate (Lh) and percentage
of osseointegration (OI) of the particles was performed to
compare the residual ridges of CG with those of the EG.
Statistical analysis of the data was performed.
Results: In the cases of the experimental group, newly-formed
bone tissue was identified around the MO-UNC particles (osseointegration).
Histomorphometric data indicate that, at 60 days post-extraction,
TAV was significantly greater for EG when compared with CG
(p<0.05) and the percentage of osseointegration of the
particles increased as a function of time (57.6 %, 90.5% y
95.5%, for EG at 15, 30 y 60 days respectively).
Conclusions: The bone matrix (MO-UNC) evaluated in this
study is an osteoconductive material that prevents the
collapse of post-extraction alveolar bone.
Key words: Bone transplantation. Alveolar ridges
preservation. Post-extraction alveoli. Osteoconductive
materials.
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